I’m interested in understanding the onset and progression of cognitive and behavioural dysfunction in neurodegenerative diseases, particularly motor neuron disease and frontotemporal dementia. I'm also interested in how other factors such as genetic status and psychiatric symptoms contribute to the presence neuropsychological impairment in neurodegenerative diseases.
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De Vocht J, Costello E, McHutchison C, Radakovic R, Foucher J, McMackin R, Peelo C, van den Berg L, Hardiman O, Van Damme P, Pender N, Abrahams S, Lulé D & first ICNALS Workshop (2026) Prioritizing neuropsychological research and care in Amyotrophic Lateral Sclerosis (ALS): building an international neuropsychological framework for ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. https://doi.org/10.1080/21678421.2025.2610290
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Utility of patient subgrouping in ALS clinical trials: a World Federation of Neurology white paper
Rosenfeld J, Abrahams S, McHutchinson C, Ajroud-Driss S, Weber M, Paganoni S, Mitsumoto H, Genge A, Grosskreutz J, Van Den Berg L, Andrews J & Kiernan MC (2025) Utility of patient subgrouping in ALS clinical trials: a World Federation of Neurology white paper. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. https://doi.org/10.1080/21678421.2025.2593308
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Jaime Garcia D, Makin SDJ, McHutchison CA, Cvoro V, Valdés Hernández MDC, Sakka E, Chappell FM, Doubal F & Wardlaw JM (2025) Functional, Cognitive, Physical, and Vascular Outcomes 9 Years After Lacunar and Mild Cortical Ischemic Stroke. Neurology, 105 (5), Art. No.: e214018. https://doi.org/10.1212/wnl.0000000000214018
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The Basis of Cognitive and Behavioral Dysfunction in Amyotrophic Lateral Sclerosis
Bampton A, McHutchison C, Talbot K, Benatar M, Thompson AG & Turner MR (2024) The Basis of Cognitive and Behavioral Dysfunction in Amyotrophic Lateral Sclerosis. Brain and Behavior, 14 (11), Art. No.: e70115. https://doi.org/10.1002/brb3.70115
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Benatar M, Macklin EA, Malaspina A, Rogers M, Hornstein E, Lombardi V, Renfrey D, Shepheard S, Magen I, Cohen Y, Granit V, Statland JM, Heckmann JM, Rademakers R & McHutchison CA (2024) Prognostic clinical and biological markers for amyotrophic lateral sclerosis disease progression: validation and implications for clinical trial design and analysis. eBioMedicine, 108, Art. No.: 105323. https://doi.org/10.1016/j.ebiom.2024.105323
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Benatar M, Wuu J, Huey ED, McMillan CT, Petersen RC, Postuma R, McHutchison C, Dratch L, Arias JJ, Crawley A, Houlden H, McDermott MP, Cai X, Thakur N & Boxer A (2024) The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology. Nature Reviews Neurology, 20, pp. 364-376. https://doi.org/10.1038/s41582-024-00961-z
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Temporal course of cognitive and behavioural changes in motor neuron diseases
McHutchison CA, Wuu J, McMillan CT, Rademakers R, Statland J, Wu G, Rampersaud E, Myers J, Hernandez JP, Abrahams S & Benatar M (2024) Temporal course of cognitive and behavioural changes in motor neuron diseases. Journal of Neurology, Neurosurgery & Psychiatry, 95, pp. 316-324. https://doi.org/10.1136/jnnp-2023-331697
