Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli

Citation

Ormsby MJ, Johnson SA, Carpena N, Meikle LM, Goldstone RJ, McIntosh A, Wessel HM, Hulme HE, McConnachie CC, Connolly JPR, Roe AJ, Hasson C, Boyd J, Fitzgerald E & Gerasimidis K (2020) Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli. Cell Reports, 30 (7), pp. 2297-2305.e5. https://doi.org/10.1016/J.CELREP.2020.01.078

Abstract
The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).

Keywords
Crohn's disease; adherent-invasive E. coli; propionic acid; short chain fatty acid

Notes
Additional co-authors: Douglas Morrison, Georgina L. Hold, Richard Hansen, Daniel Walker, David G.E. Smith, Daniel M. Wall

Journal
Cell Reports: Volume 30, Issue 7

• Published version